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Phoenix™ WinNonlin® Features

Key features of Phoenix WinNonlin include the following:

Comprehensive Analysis Environment

  • One Maximum Likelihood and 3 Least Squares methods for analysis of individual profiles (PK, PD)
  • Non-Compartmental analysis using 4 methods of AUC calculation
  • Non-Compartmental analysis for PK rich datasets, PK Sparse Data, and Pharmacodynamic Data.
  • Descriptive statistics, including weighted descriptive statistics.
  • Units definition and conversions, including the ability to specify preferred output units, units for a dosing regimen, and unit conversions.
  • Powerful data management tools allow users to append worksheets, change properties and/or transform columns, add BQL Rules or map cross product worksheets, as well as filter, join, merge, pivot, rank, split, and stack data.
  • Tools for deconvolution, semicompartmental modeling, nonparametric superposition and crossover design.
  • Automatic determination of initial estimates of Least Square methods. Interactive graphical preview methods to determine initial estimates for maximum likelihood engine.
  • Analysis using general linear modeling approaches, including bioequivalence tests as appropriate.
  • Built-in Library, Graphical and Textual (Pharsight Modeling Language or PML) options on how to build models.

Efficient Workflow Management

  • Workflow management tools that enable users to create, reuse, and share models and projects.
  • More powerful data management tools. Excel compatible workbooks, including formulas, functions, data import/export, missing value codes, sort, transformations and worksheet merge.
  • Insert favorite workflow components and/or sub-workflows into larger workflow diagrams.
  • Easily map data inputs to multiple models.

High Quality Outputs

  • Built-in Table templates and option to customize table templates for tabulation of results
  • Formatting options for tabulating results using subscripts, superscripts, symbols, titles, footnotes, and many other formats.
  • Significantly improved, report-ready graphs, plots, tables and listings greatly reduce the reliance on external graphics software.
  • Easily insert bar, column, and box plots; histograms; XY, QQ plots, and/or scatter plot matrices into your workflows.
  • Easily change the formatting of any plot to suit reporting requirements.
  • One-click export of results, plots, and tables to Microsoft ExcelŽ or WordŽ, SAS, graphic files, or text.

Easy to Learn and Share

  • An intuitive user interface provides multiple click-paths to accomplish the same tasks, allowing users to use the software in ways that make suit their personal preferences.
  • All data, models, scripts, tables, BQL rules, documents, models, workflows, plots, graphs, and outputs are contained in one project file that can easily be shared.
  • Classroom and online training courses will be offered regularly to support new users.

Enables Compliance

  • Every workflow object has a 'Verification' tab that explains whether the object executed properly and any errors that may have occurred.
  • Full integration with the Pharsight Knowledgebase Server? (PKS?) data repository enabling all changes to projects to be logged in the PKS database
  • Validation can be speeded up significantly with the Phoenix Validation Suite?.

 

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