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Trial Simulator Features

Key features of the Pharsight Trial Simulator include:

Flexible Trial Design

  • Specify treatment protocols, inclusion criteria, and observations.
  • Define realistic subject populations through covariate distribution models.
  • Define compliance and dropouts based on drug effects or time.
  • Model variability in the actual time doses are taken or observations are made.

Powerful Modeling

  • Model drug effects as a function of dose(s), disease processes, time and subject characteristics.
  • Estimate measurement error as well as biological and unexplained variability.
  • Use the patented, component-driven graphical interface for rapid, intuitive modeling.
  • Rely on a broad library of pre-defined model components or write your own FORTRAN.
  • Automate simulations through Visual Basic or other scripts.
  • Save models as editable text files or XML.
  • Swap and test model segments using "include sets."
  • Compile simulation models through Compaq Digital Fortran, or Intel Visual Fortran.

Integrated Analysis Tools and Data Export

  • Export data to SAS, S-PLUS®, NONMEM®, WinNonlin® and more.
  • Special version of S-PLUS Professional for Trial Simulator included.
  • Perform descriptive statistics, ANOVA, survival analysis, and custom S-PLUS analyses on each trial replicate and as meta-analysis across replicates.
  • Plot results through a connection to S-PLUS.
  • Save simulation output in a Microsoft Access database or performance-enhancing binary format.

 

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