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WinNonlin® AutoPilot Features

Key features of WinNonlin® AutoPilot include:

  • Wizard-based interface to input clinical PK study data, define analyses and specify output to match your organization's SOPs and best practices.
  • Seamless links for analysis execution to WinNonlin® and to SigmaPlot®, Microsoft® Word and Excel® for presentation of formatted tabular and graphical output.
  • Utility to allow convenient browsing through generated WinNonlin AutoPilot output, selection of files for use in interim or final reports, and interactive transfer of the selected output files into Microsoft Word or PowerPoint® documents.
  • Configurable administrator tool for easy application of factory default settings or to readily modify settings for selected outputs, output formats, and business rules to efficiently implement your organization's analysis and reporting requirements.
  • Ability to save customer-defined settings as separate configuration files (unlimited number of files may be created) for flexible execution and reporting of a drug sponsor's PK analyses.
  • Wizard-based comparisons of analysis runs (e.g., plasma analyte, accumulation) and creation of additional display outputs.
  • Ability to operate on study data and models from your local file system (AutoPilot Standard Edition) as well as in a controlled PK data management system based on Pharsight Knowledgebase Server™ (AutoPilot PKS Edition).
  • Full integration with the Pharsight Knowledgebase Server for secure storage and change tracking of input data, analysis settings, results and reports (AutoPilot PKS Edition).
  • Online Help system detailing usage instructions as well as data requirements, analysis settings and output specifications.

WinNonlin AutoPilot can automate any analysis and produce any output (e.g. tables, text and figures) currently created through WinNonlin. WinNonlin AutoPilot also provides comparisons of WinNonlin output. Typical PK analyses that can be automated include IV- or PO-based non-compartmental analysis and inferential statistics (e.g., bioequivalence testing) as well as comparisons between analytes, dose routes or other conditions.

Study datasets can be organized as stacked or non-stacked data. Examples of common study design types that WinNonlin AutoPilot supports include:

  • Bioequivalence and Bioavailability
  • Drug-Drug and Food-Drug interactions
  • First-in-man
  • Dose Proportionality
  • Special Populations (e.g. renal, hepatic, age)